Researchers explore cellular uptake, endocytic pathways, and intracellular dynamics of nanoparticles in HeLa cells, both in absence and presence of biomolecular corona from human plasma. They find that the biomolecular corona could act as a personalized ‘endogenous trigger’ affecting off-target interactions and controlling the indication for disease of clinically approved formulations. Mechanistic investigations of the biomolecular corona could contribute to a better understanding of the poor success of targeted liposomal technology. […]
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