The purpose of this study was to explore the factor structure and psychometric properties of the Chinese version of Family Quality of Life Questionnaire (Chinese FQoL-Q) for children with developmental disabilities (CDD) under the background of Chinese culture. The item analysis, exploratory factor analysis, confirmatory factor analysis, and reliability test were carried out on survey data from a sample of 845 families of CDD. It was found that the Chinese FQoL-Q involved seven factors with 35 items, including economy and leisure, physical and mental health, parenting, family communication, support from others, professional support, and career development. The measurement model of Chinese FQoL-Q reflected traditional Chinese culture and parents’ perception of education or rehabilitation for CDD in China. The Chinese FQoL-Q is reliable and valid for assessing the quality of life for family members with developmental disabilities.